EJ Anderson Lab

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Basic Science

Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson EJ, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Circulation. 2017 Jan 3;135(1):73-88. doi: 10.1161/CIRCULATIONAHA.116.022281.

La Favor JD, Dubis GS, Yan H, White JD, Nelson MA, Anderson EJ, Hickner RC. Microvascular Endothelial Dysfunction in Sedentary, Obese Humans is Mediated by NADPH Oxidase: Influence of Exercise Training.

Arterioscler Thromb Vasc Biol. 2016 Oct 20. pii: ATVBAHA.116.308339. [Epub ahead of print]

Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD. Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers. Am J Physiol-Cell Mol Physiol. 2016 Aug 1;311(2):C239-45. doi: 10.1152/ajpcell.00124.2016. Epub 2016 Jun 22.

 

Grevengoed TJ, Martin SA, Katunga L, Cooper DE, Anderson EJ, Murphy RC, et al. Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. J Lipid Res. 2015;56(8):1572-82.

 

Katunga LA, Gudimella P, Efird JT, Abernathy S, Mattox TA, Beatty C, et al. Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. Molecular metabolism. 2015;4(6):493-506.

 

Kang L, Dai C, Lustig ME, Bonner JS, Mayes WH, Mokshagundam S, et al. Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice. Diabetes. 2014;63(11):3699-710.

 

Mattox TA, Young ME, Rubel CE, Spaniel C, Rodriguez JE, Grevengoed TJ, et al. MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo. Journal of bioenergetics and biomembranes. 2014;46(3):173-87.

 

Anderson EJ, Thayne KA, Harris M, Shaikh SR, Darden TM, Lark DS, et al. Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocardium via PPARgamma activation? Antioxidants & redox signaling. 2014;21(8):1156-63.

 

Anderson EJ, Efird JT, Davies SW, O'Neal WT, Darden TM, Thayne KA, et al. Monoamine oxidase is a major determinant of redox balance in human atrial myocardium and is associated with postoperative atrial fibrillation. J Am Heart Assoc. 2014;3(1):e000713.

 

Rogers C, Davis B, Neufer PD, Murphy MP, Anderson EJ, Robidoux J. A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids. Free radical biology & medicine. 2014;67:330-41.

 

Virag JA, Anderson EJ, Kent SD, Blanton HD, Johnson TL, Moukdar F, et al. Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium. American journal of physiology Heart and circulatory physiology. 2013;305(4):H477-83.

 

La Favor JD, Anderson EJ, Dawkins JT, Hickner RC, Wingard CJ. Exercise prevents Western diet-associated erectile dysfunction and coronary artery endothelial dysfunction: response to acute apocynin and sepiapterin treatment. American journal of physiology Regulatory, integrative and comparative physiology. 2013;305(4):R423-34.

 

Fisher-Wellman KH, Mattox TA, Thayne K, Katunga LA, La Favor JD, Neufer PD, et al. Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle. The Journal of physiology. 2013;591(Pt 14):3471-86.

 

La Favor JD, Anderson EJ, Hickner RC, Wingard CJ. Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, Western pattern diet. The journal of sexual medicine. 2013;10(3):694-703.

 

Kang L, Lustig ME, Bonner JS, Lee-Young RS, Mayes WH, James FD, et al. Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet. J Appl Physiol (1985). 2012;113(8):1173-83.

 

Kwak HB, Thalacker-Mercer A, Anderson EJ, Lin CT, Kane DA, Lee NS, et al. Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free radical biology & medicine. 2012;52(1):198-207.

 

Frasier CR, Sloan RC, Bostian PA, Gonzon MD, Kurowicki J, Lopresto SJ, et al. Short-term exercise preserves myocardial glutathione and decreases arrhythmias after thiol oxidation and ischemia in isolated rat hearts. J Appl Physiol (1985). 2011;111(6):1751-9.

 

Anderson EJ, Thayne K, Harris M, Carraway K, Shaikh SR. Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids. The Biochemical journal. 2012;441(1):359-66.

 

Perry CG, Kane DA, Lin CT, Kozy R, Cathey BL, Lark DS, et al. Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle. The Biochemical journal. 2011;437(2):215-22.

 

Kane DA, Lin CT, Anderson EJ, Kwak HB, Cox JH, Brophy PM, et al. Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women. American journal of physiology Endocrinology and metabolism. 2011;300(3):E528-35.

 

Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP. Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. American journal of physiology Heart and circulatory physiology. 2011;300(1):H118-24.

 

Kane DA, Anderson EJ, Price JW, 3rd, Woodlief TL, Lin CT, Bikman BT, et al. Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats. Free radical biology & medicine. 2010;49(6):1082-7.

 

Brown DA, Aon MA, Frasier CR, Sloan RC, Maloney AH, Anderson EJ, et al. Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. J Mol Cell Cardiol. 2010;48(4):673-9.

 

Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol. 2009;54(20):1891-8.

 

Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, et al. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest. 2009;119(3):573-81.

 

 

Epidemiology

Efird JT, Kiser AC, Crane PB, Landrine H, Kindell LC, Nelson MA, Jindal C, Sarpong DF, Griffin WF, Ferguson TB, Chitwood WR, Davies SW, Kypson AP, Gudimella P, Anderson EJ. Perioperative Inotrope Therapy and Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery: Evidence of a Racial Disparity.  Pharmacotherapy. 2017 Jan 4. doi: 10.1002/phar.1894. [Epub ahead of print]

Efird JT, Gudimella P, O’Neal WT, Griffin WF, Landrine H, Kindell LC, et al. Comparison of Risk of Atrial Fibrillation among Black versus White Patients Following Coronary Artery Bypass Grafting. Am J Cardiol. 2016 Apr 1;117(7):1095-100.

 

Efird JT, Griffin WF, Gudimella P, O’Neal WT, Davies SW, Crane PB, et al. Conditional long-term survival following minimally invasive robotic mitral valve repair: a health services perspective. Ann Cardiothorac Surg 2015;4(5):433-442.

 

Efird JT, Griffin WF, Sarpong DF, Davies SW, Vann I, Koutlas NT, et al. Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents. Int J Environ Res Public Health. 2015;12(7):7478-90.

 

Efird JT, O'Neal WT, Griffin WF, Anderson EJ, Davies SW, Landrine H, et al. Increased coronary artery disease severity in black women undergoing coronary bypass surgery. Medicine (Baltimore). 2015;94(7):e552.

 

Efird JT, Davies SW, O'Neal WT, Anderson CA, Anderson EJ, O'Neal JB, et al. The impact of race and postoperative atrial fibrillation on operative mortality after elective coronary artery bypass grafting. Eur J Cardiothorac Surg. 2014;45(2):e20-5.

Reviews/Editorials

Anderson EJ. Cutting Calories and TXNIP From the Skeletal Muscle to Restore Insulin Sensitivity. Diabetes. 2016;65(1):16-8.

 

Alleman RJ, Katunga LA, Nelson MA, Brown DA, Anderson EJ. The "Goldilocks Zone" from a redox perspective-Adaptive vs. deleterious responses to oxidative stress in striated muscle. Frontiers in physiology. 2014;5:358.

 

Efird JT, Davies SW, O'Neal WT, Anderson EJ. Animal viruses, bacteria, and cancer: a brief commentary. Front Public Health. 2014;2:14.

 

Anderson EJ, Katunga LA, Willis MS. Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart. Clin Exp Pharmacol Physiol. 2012;39(2):179-93.

 

Anderson EJ, Taylor DA. Stressing the heart of the matter: re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids. F1000 medicine reports. 2012;4:13.